Table 2.

Pharmacokinetic models utilized in each study.

	Pharmacokinetic Model	Parameters	Study
Tofts	$C_t\left(t\right)=K^{Trans}{{\displaystyle \int }}_0^t{C}_p\left(\tau \right)e^{\frac{K^{Trans}}{v_e}\left(\tau -t\right)}d\tau$	$K^{Trans}$, $v_e$	Winter (2015), Yoo (2018) [12,14]
Extended Tofts	$C_t\left(t\right)=v_p{C}_p\left(t\right)+K^{Trans}{{\displaystyle \int }}_0^t{C}_p\left(\tau \right)e^{\frac{K^{Trans}}{v_e}\left(\tau -t\right)}d\tau$	$K^{Trans}$, $v_p$, $v_e$	Yoen (2021) [13]
Patlak	$C_t\left(t\right)=v_p{C}_p\left(t\right)+K^{Trans}{{\displaystyle \int }}_0^t{C}_p\left(\tau \right)d\tau$	$K^{Trans}$, $v_p$	Yoen (2021) [13]

$C_t$, tracer concentration in tissue; $K^{Trans}$, volume transfer constant; $C_p$, tracer concentration in blood plasma; $v_e$, extravascular extracellular space (EES) volume fraction; $v_p$, blood plasma volume fraction.