Skip to main content
. 2021 Jun 11;22(12):6293. doi: 10.3390/ijms22126293
θ hydrogen bond angle
# hydrogen bond components: from the protein
% hydrogen bond components: from the ligand
acc hydrogen bond acceptor
ADT AutoDockTools
CHO Chinese hamster ovary
CNS central nervous system
CSF cerebrospinal fluid
DA dopamine
DAT proteins of dopamine transporter
EB complex energy binding
EHB hydrogen bond energy
GABA γ-aminobutyric acid
GAT1 GABA transporter isoform 1
GAT2 GABA transporter isoform 2
GAT3 GABA transporter isoform 3
GDA generalized anxiety disorder
hSERT human proteins of serotonin transporter
hDAT human proteins of dopamine transporter
hNET human proteins of norepinephrine transporter
hGAT1 human GABA transporter isoform 1
hGAT2 human GABA transporter isoform 2
hGAT3 human GABA transporter isoform 3
hBGT1 human betaine/GABA transporter
LHB hydrogen bond length
MAT monoamine transporters
MDD major depressive disorder
NE norepinephrine
NET proteins of norepinephrine transporter
NPC neural progenitor cells
NSC neural stem cells
OCD obsessive-compulsive disorder
PD panic disorder
PDB ID Protein Data Bank Identifier
pIC50xxx inhibitory potency of xxx transporters
pKixxx binding affinity of xxx transporters
PMDD premenstrual dysphoric disorder
PRX paroxetine
PTSD post traumatic stress disorder
R/S-NE R/S enantiomers norepinephrine
RMS root mean square
SAD social anxiety disorder
SER serotonin
SERT proteins of serotonin transporter
SNRI serotonin norepinephrine reuptake inhibitors
SSRI selective serotonin reuptake inhibitors
TCA tricyclic antidepressants
Tsc Tanimoto similarity coefficient
TM transmembrane segments
TMH transmembrane segments helix