Skip to main content
. 2021 Jun 11;13(6):865. doi: 10.3390/pharmaceutics13060865

Table 6.

Cell replacement clinical trials for retinal vascular diseases.

Reference Cell Type Title Disease Administration Procedure Status
NCT01518842
Not applicable
Bone marrow stem cells Effect of Intravitreal Bone Marrow Stem Cells on Ischemic Retinopathy (RetinaCell) Ischemic retinopathy, including diabetic retinopathy with severe loss of retinal capillaries Intravitreal Unknown
NCT01736059
Phase I Study
CD34+ autologous adult bone marrow stem cells intravitreal Clinical Trial of Autologous Intravitreal Bone-marrow CD34+ Stem Cells for Retinopathy Non-exudative age-related macular degeneration
Diabetic retinopathy
Retina vein occlusion
Retinitis pigmentosa
hereditary macular degeneration
Intravitreal Enrolling by invitation
NCT03981549
Phase I/II Study
CD34+ autologous bone marrow stem cells
versus sham therapy
Treatment of Central Retinal Vein Occlusion Using Stem Cells Study (TRUST) Central retinal vein occlusion Intravitreal Recruiting
NCT03403699
Not applicable
Combination of CD34+CD45+ cells derived from human inducible pluripotent stem cells (iPSCs) with iPSCs derived from the mesoderm: vascular wall-derived progenitor cells or endothelial colony forming cells (ECFCs) subset (SSEA5-KNA+) Human iPSC for Repair of Vasodegenerative Vessels in Diabetic Retinopathy Diabetes complications
Diabetic retinopathy
Others: to test if the hiPSC-derived-mesoderm subset (SSEA5-KNA+) can revascularize vasodegenerative capillaries and if their reparative action can be enhanced by coinjection of CD34+CD45+ cells intravitreally. Recruiting
NCT03264976
Not applicable
None Role of the Serum Exosomal miRNA in Diabetic Retinopathy (DR) Diabetic retinopathy Validation of a diagnostic test based on exosomal miRNAs in serum samples that will be sequenced Not yet recruiting