Figure 1.

Schema showing drug administration and in vivo testing protocols used in the present study. (A) The intervention protocol used to measure the effects of single-dose or repeated-dose minocycline, ambroxol and duloxetine used alone or in combination on tactile allodynia in the von Frey test and cold hyperalgesia in the cold plate test in oxaliplatin-treated mice. (B) The protocol used for the measurement of the impact of these drugs on animals’ motor coordination assessed in the rotarod test. Abbreviations: CPT—cold plate test; vFT—von Frey test; OXA—oxaliplatin.