Table 1.
Effect of test drugs administered in a single-dose or repeated-dose protocol and used alone or in combination on motor coordination of oxaliplatin-treated mice measured in the rotarod test.
| Treatment (Drug, Dose, Protocol) |
Mean Time [s] (±SEM) on the Rotarod Revolving at: | ||
|---|---|---|---|
| 6 rpm | 18 rpm | 24 rpm | |
| Veh | 60.0 ± 0.0 | 60.0 ± 0.0 | 47.0 ± 8.5 |
| Veh + oxa | 60.0 ± 0.0 | 60.0 ± 0.0 | 60.0 ± 0.0 |
| Oxa + Mino 50 single day 1 |
54.8 ± 5.3 | 60.0 ± 0.0 | 53.0 ± 7.0 |
| Oxa + Mino 50 single day 7 |
60.0 ± 0.0 | 60.0 ± 0.0 | 60.0 ± 0.0 |
| Oxa + Mino 50 repeated day 7 | 60.0 ± 0.0 | 60.0 ± 0.0 | 60.0 ± 0.0 |
| Oxa + Mino 100 single day 1 | 46.8 ± 8.7 | 48.3 ± 7.7 | 36.5 ± 9.1 |
| Oxa + Mino 100 single day 7 | 46.0 ± 5.6 | 43.8 ± 10.2 | 42.7 ± 9.6 |
| Oxa + Mino 100 repeated day 7 | 51.6 ± 5.5 | 60.0 ± 0.0 | 55.8 ± 2.8 |
| Oxa + Mino 50 + Am 90 single day 1 | 57.5 ± 2.5 | 60.0 ± 0.0 | 58.3 ± 1.8 |
| Oxa + Mino 50 + Am 90 single day 7 | 60.0 ± 0.0 | 60.0 ± 0.0 | 60.0 ± 0.0 |
| Oxa + Mino 50 + Am 90 repeated day 7 | 60.0 ± 0.0 | 60.0 ± 0.0 | 60.0 ± 0.0 |
| Oxa + Dulo 10 single day 1 |
60.0 ± 0.0 | 49.6 ± 5.2 | 54.3 ± 3.8 |
| Oxa + Dulo 10 single day 7 |
52.9 ± 4.7 | 16.8 ± 3.5 **** | 9.6 ± 1.7 **** |
| Oxa + Dulo 10 repeated day 7 | 60.0 ± 0.0 | 56.5 ± 2.3 | 56.0 ± 2.6 |
| Oxa + Dulo 30 single day 1 |
49.3 ± 7.0 | 36.0 ± 6.8 ** | 23.5 ± 8.3 *** |
| Oxa + Dulo 30 single day 7 |
44.7 2 6.0 | 49.5 ± 5.6 | 16.0 ± 2.8 **** |
| Oxa + Dulo 30 repeated day 7 | 54.8 ± 3.4 | 60.0 ± 0.0 | 28.8 ± 8.2 ** |
| Oxa + Mino 50 + Dulo 10 single day 1 | 60.0 ± 0.0 | 49.8 ± 6.7 | 57.4 ± 1.7 |
| Oxa + Mino 50 + Dulo 10 single day 7 | 60.0 ± 0.0 | 60.0 ± 0.0 | 48.9 ± 7.3 |
| Oxa + Mino 50 + Dulo 10 repeated day 7 | 60.0 ± 0.0 | 49.4 ± 7.0 | 47.8 ± 7.2 |
The results are shown as the mean time [s] (± SEM) spent on the rotarod apparatus revolving at 6, 18, and 24 rpm for n = 6–8. Statistical analysis: one-way ANOVA followed by Tukey’s post-hoc comparison. Significance vs. vehicle + oxaliplatin-treated mice: ** p < 0.01, *** p < 0.001, **** p < 0.0001. Abbreviations: Veh—vehicle, Oxa—oxaliplatin, Mino—minocycline, Am—ambroxol, Dulo—duloxetine.