Table 1.
Overall baseline characteristics (n = 239) and baseline characteristics of participants stratified by quartiles distributed according to pretransplant serum uromodulin (sUMOD).
| Characteristics | Total | Quartile 1 sUMOD: <2.59 ng/mL |
Quartile 2 sUMOD: 2.59–7.04 ng/mL |
Quartile 3 sUMOD: >7.04–14.66 ng/mL |
Quartile 4 sUMOD: >14.66 ng/mL |
p-Value |
|---|---|---|---|---|---|---|
| Number (no.) of patients | 239 | 60 | 60 | 59 | 60 | |
| Recipient demographics | ||||||
| Age [years] | 51 ± 14 | 50 ± 14 | 54 ± 13 | 52 ± 14 | 49 ±16 | 0.185 |
| Female, no. (%) | 75 (31.4) | 17 (28.3) | 20 (33.3) | 15 (25.4) | 23 (38.3) | 0.443 |
| Body-mass index [kg/m2] | 25.3 ± 4.8 | 25.0 ± 5.1 | 25.6 ± 5.1 | 26.0 ± 4.8 | 24.8 ± 4.3 | 0.525 |
| Diabetes, no. (%) | 48 (20.1) | 4 (6.7) | 18 (30.0) | 15 (25.4) | 11 (18.3) | 0.009 |
| Hypertension, no. (%) | 194 (81.2) | 46 (76.7) | 51 (85.0) | 50 (84.7) | 47 (78.3) | 0.536 |
| Cardiovascular disease, no. (%) | 79 (33.1) | 18 (30.0) | 25 (41.7) | 22 (37.3) | 14 (23.3) | 0.151 |
| Dialysis vintage [days] | 1559 ± 1418 | 2137 (1469) | 1921 ± 1392 | 1220 ± 1267 | 953 ± 1215 | <0.001 |
| Preemptive transplant, no. (%) | 29 (12.1) | 3 (5.0) | 1 (1.7) | 7 (11.9) | 18 (30.0) | <0.001 |
| Pretransplant sUMOD [ng/mL] | 14.9 ± 23.8 | 0.9 ± 0.8 | 4.5 ± 1.3 | 10.1 ± 2.0 | 44.2 ± 32.8 | <0.001 |
| Recipient laboratory measures on postoperative Day 1 (POD1) | ||||||
| sUMOD [ng/mL] | 52.3 ± 50.2 | 56.0 ± 65.1 | 50.6 ± 51.1 | 36.4 ± 24.5 | 65.3 ± 48.7 | 0.014 |
| Serum creatinine [mg/dL] | 6.0 ± 2.3 | 6.0 ± 2.1 | 6.7 ± 2.4 | 6.1 ± 2.4 | 5.2 ± 2.2 | 0.004 |
| Hemoglobin [g/dL] | 10.3 ± 1.6 | 10.3 ± 1.8 | 10.6 ± 1.6) | 10.5 ± 1.4 | 10.0 ± 1.6 | 0.223 |
| Leucocyte count [G/L] | 11.6 ± 4.2 | 10.6 ± 3.8 | 11.7 ± 3.8 | 11.6 ± 4.5 | 12.6 ± 4.5 | 0.095 |
| C-reactive protein [mg/dL] | 3.4 ± 2.3 | 2.6 ± 1.4 | 6.0 ± 3.6 | 3.2 ± 1.7 | 2.8 ± 1.6 | <0.001 |
| Sodium [mmol/L] | 141 ± 4 | 140 ± 4 | 141 ± 4 | 141± 5 | 141 ± 4 | 0.093 |
| Potassium [mmol/L] | 4.9 ± 0.8 | 5.1 ± 0.7 | 5.0 ± 0.8 | 4.7 ± 0.7 | 4.6 ± 0.8 | <0.001 |
| Donor characteristics | ||||||
| Age [years] | 54.4 ±15.5 | 51 ± 16 | 55 ±16) | 55 ± 15) | 52 ± 15 | 0.256 |
| Female, no. (%) | 118 (49.4) | 25 (41.7) | 32 (53.3) | 29 (49.2) | 32 (53.3) | 0.536 |
| Body-mass index [kg/m2] | 26.4 ± 4.4 | 27.0 ± 5.2 | 26.0 ± 3.7 | 26.5 ± 4.5 | 26.1 ± 3.8 | 0.574 |
| Diabetes, no. (%) | 0.131 | |||||
| No | 166 (69.5) | 37 (61.7) | 46 (76.7) | 35 (59.3) | 48 (80.0) | |
| Yes | 15 (6.3) | 4 (6.7) | 4 (6.7) | 5 (8.5) | 2 (3.3) | |
| Unknown | 58 (24.3) | 19 (31.7) | 10 (16.7) | 19 (32.2) | 10 (16.7) | |
| Hypertension, no. (%) | 0.071 | |||||
| No | 119 (49.8) | 29 (48.3) | 30 (50.0) | 23 (39.0) | 37 (61.7) | |
| Yes | 79 (33.1) | 16 (26.7) | 22 (36.7) | 27 (45.8) | 14 (23.3) | |
| Unknown | 41 (17.2) | 15 (25.0) | 8 (13.3) | 9 (15.3) | 9 (15.0) | |
| Serum creatinine [mg/dL] | 1.0 ± 0.7 | 1.0 ± 0.8 | 0.9 ± 0.5) | 1.1 ± 0.8 | 1.0 ± 0.7 | 0.740 |
| Expanded criteria donor, no (%) | 97 (40.6) | 20 (33.3) | 28 (46.7) | 28 (47.5) | 21 (35.0) | 0.245 |
| Transplant related variables | ||||||
| Living donation, no. (%) | 90 (37.7) | 14 (23.3) | 14 (23.3) | 27 (45.8) | 35 (58.3) | <0.001 |
| Cold ischemic time [hours] | 8 ± 6 | 10 ± 6 | 10 ± 6 | 7 ± 5 | 6 ± 6 | <0.001 |
| Warm ischemic time [minutes] | 25 ± 13 | 26 ± 12 | 27 ± 13 | 27 ± 16 | 23 ± 7 | 0.313 |
| Primary non-function, no. (%) | 8 (3.3) | 1 (1.7) | 2 (3.3) | 3 (5.1) | 2 (3.3) | 0.783 |
| No. of HLA-mismatches | 4 ± 2 | 4 ± 2 | 4 ± 2 | 3 ± 2 | 3 ± 2 | 0.410 |
Continuous variables presented as mean ± standard deviation, categorical variables presented in percentage of referring population. The p-value will compare variables between quartiles calculated by parametric testing. sUMOD, serum uromodulin.