Table 3.
Associations of serum uromodulin (sUMOD) pretransplant and on postoperative Day 1 with delayed graft function (DGF) in the kidney transplant.
| Events | Unadjusted | Model 1 a | Model 2 b | Model 3 c | |
|---|---|---|---|---|---|
| Pretransplant sUMOD | |||||
| Per 10 ng/mL higher sUMOD | 64/239 | 0.51 (0.32–0.73) | 0.54 (0.31–0.81) | 0.55 (0.31–0.83) | 0.53 (0.30–0.82) |
| Q1 | 25/60 | 5.41 (2.21–14.80) | 4.47 (1.62–13.61) | 4.30 (1.53–13.31) | 4.41 (1.54–13.93) |
| Q2 | 20/60 | 3.79 (1.52–10.46) | 2.55 (0.93–7.61) | 1.94 (0.68–5.93) | 1.95 (0.67–6.08) |
| Q3 | 12/59 | 1.93 (0.72–5.58) | 1.52 (0.52–4.70) | 1.28 (0.42–4.06) | 1.29 (0.42–4.14) |
| Q4 | 7/60 | 1 (ref.) | 1 (ref.) | 1 (ref.) | 1 (ref.) |
| sUMOD on postoperative Day 1 | |||||
| Per 10 ng/mL higher sUMOD | 63/237 * | 1.01 (0.95–1.07) | 1.01 (0.95–1.07) | 1.03 (0.96–1.09) | 1.03 (0.96–1.09) |
| Q1 | 16/60 | 0.90 (0.40–2.01) | 0.71 (0.28–1.75) | 0.70 (0.27–1.78) | 0.71 (0.27–1.86) |
| Q2 | 14/59 | 0.77 (0.33–1.74) | 0.72 (0.27–1.85) | 0.77 (0.29–2.03) | 0.79 (0.29–2.14) |
| Q3 | 16/59 | 0.92 (0.41–2.06) | 0.84 (0.34–2.07) | 0.88 (0.35–2.22) | 0.86 (0.34–2.17) |
| Q4 | 17/59 | 1 (ref.) | 1 (ref.) | 1 (ref.) | 1 (ref.) |
Results are presented as odds ratios with 95%-confidence intervals given in parentheses. Delayed graft function is defined as the requirement of >1 dialysis treatment within the first week after transplantation. Quartile distribution according to preoperative serum uromodulin (sUMOD): Quartile 1 (Q1) ≤ 2.59 ng/mL, Quartile 2 (Q2) > 2.59–7.04 ng/mL, Quartile 3 (Q3) > 7.04–14.66 ng/mL, Quartile 4 (Q4) > 14.66 ng/mL. Quartile distribution according to postoperative Day 1 serum uromodulin (sUMOD): Quartile 1 (Q1) ≤ 22.00 ng/mL, Quartile 2 (Q2) > 22.00–36.97 ng/mL, Quartile 3 (Q3) > 36.97–68.44 ng/mL, Quartile 4 (Q4) > 68.44 ng/mL. * Two patients missing due to missing sUMOD values on postoperative Day 1. a Adjusted for recipients age, recipients body-mass-index and dialysis vintage. b Model 1 + serum creatinine on postoperative Day 1. c Model 2 + cold-ischemia time, living vs. deceased donor transplantation, expanded criteria donors (ECD).