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. Author manuscript; available in PMC: 2021 Oct 6.
Published in final edited form as: J Neurooncol. 2020 Oct 6;150(1):47–56. doi: 10.1007/s11060-020-03639-w

Figure 2. Histological features of ATRT.

Figure 2.

A) The hypercellular tumor is usually predominantly composed of primitive-appearing cells with scant cytoplasm and hyperchromatic nuclei. Mitotic figures, apoptotic bodies and necrosis may all be readily identified. B) A subset of cells may show abundant, globular eosinophilic cytoplasm, reminiscent of rhabdoid cells. C) SMARCB1 (INI1 / BAF47 / SNF5) immunohistochemistry shows uniform loss of expression in the tumor cells, while expression is retained in endothelial nuclei serving as positive internal controls. (A, B – Hematoxylin and Eosin stain, 400x magnification; C – BAF47 clone (BD Biosciences), 200x magnification).