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. Author manuscript; available in PMC: 2021 Oct 6.
Published in final edited form as: J Neurooncol. 2020 Oct 6;150(1):47–56. doi: 10.1007/s11060-020-03639-w

Figure 3. Enhancer landscape in ATRT and specificity to molecular subtypes.

Figure 3.

Loss of SMARCB1 results in selective loss of typical enhancers (TEs) involved in cell lineage determination via residual activity of the SWI/SNF complex, loss of histone acetylase activity and increased relative PRC2/EZH2 activity. However, super enhancer (SE) activity is selectively retained at genes that contribute to cell proliferation and immortality in one of three specific patterns. These three molecular subgroups of ATRT are relevant to developing logical, targeted therapies and potentially prognostication.