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. 2021 Jun 11;11:639177. doi: 10.3389/fcimb.2021.639177

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Copyright © 2021 Pires de Souza, Osman, Le Bideau, Baudoin, Jaafar, Devaux and La Scola

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of Angiotensin II receptor type 1 (AT1R) and Angiotensin-converting enzyme 2 (ACE2) mRNAs and proteins by VERO E6 cells following 72 hours incubation with different Angiotensin II Receptor Blockers (ARBs). Non-cytotoxic concentrations of ARBs (Azil, Azilsartan 15µM; Epr, Eprosartan 30µM; Irb, Irbesartan 60µM; Los, losartan 7µM; Olm, Olmesartan 15µM; Tel, Telmisartan 7µM; Val, Valsartan 7µM) were previously defined by the MTT assay and cells were treated with the various ARBs. (A) Relative expression of the ACE2/ACEH gene in untreated (Unt) and ARB-treated Vero E6 cells. (B) Relative expression of the ATR1/AGTR1 gene in untreated versus ARB-treated Vero E6 cells. (C) Expression of ACE2 protein in untreated versus ARB-treated Vero E6 cells (the membrane-anchored ACE2 glycosylated protein that acts as receptor for SARS-CoV-2 is the 110kDa form of the molecule).