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. 2021 Jun 11;11:629860. doi: 10.3389/fonc.2021.629860

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Copyright © 2021 Huang, Fu, Zhang, Xu, Li, Onwuka, Zhang, Zhao, Sun, Zhu, Zheng, Jia, Cui and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of methylation-driven genes in CRC patients. (A) Heat map of 143 CRC-related methylation-driven genes. The color change from green to red illustrates a trend from hypomethylation to hypermethylation. |log FC|≥0, adjusted P < 0.05, and Cor <−0.5. CRC, colorectal cancer; FC, fold change. (B) Selection of driven genes in the LASSO model. (C) Tuning parameter (λ) selection in the LASSO model used cross-validation via the maximum criteria. The dotted vertical lines were drawn at the optimal values using the maximum criteria and the one standard error of the maximum criteria.