Table 3.

Univariable and multivariable Cox regression analyses of the four methylation-driven genes signature and survival of CRC patients in the training and testing sets.

Variables	Training set (N = 367)				Testing set (N = 355)
	95% CI				95% CI
	HR	Lower	Upper	P	HR	Lower	Upper	P
Univariable analysis
Age
≥65 years vs <65 years	2.170	1.328	3.547	0.002	0.938	0.702	1.253	0.664
Sex
Male vs female	1.449	0.923	2.274	0.107	0.958	0.717	1.282	0.774
TNM stage
III+IV vs I + II	2.765	1.741	4.391	0.000	4.251	2.742	6.591	0.000
Four genes signature
High risk vs low risk	2.351	1.472	3.755	0.000	1.963	1.456	2.647	0.000
Multivariable analysis
Age
≥65 years vs<65 years	2.355	1.421	3.903	0.001	1.270	0.942	1.712	0.117
Sex
Male vs female	1.123	0.712	1.771	0.618	0.942	0.702	1.264	0.690
TNM stage
III+IV vs I + II	3.291	2.049	5.286	0.000	3.967	2.508	6.274	0.000
Four genes signature
High risk vs low risk	2.221	1.382	3.571	0.001	1.436	1.051	1.962	0.023