Table 1.
Size and characteristics of the IBS 16S rRNA datasets included in this study.
| Dataset | Groups (n) | Age (average ± sd.) | BMI (average ± sd.) | Sex F/M | Country | Data storage (NCBI SRA) | Amplification region | Sequencing method |
|---|---|---|---|---|---|---|---|---|
| Zhuang_2018 (Zhuang et al., 2018) | HC (13) | 30.54 ± 6.75 | 20.84 ± 1.46 20.61 | 8/5 21/9 | China | SRP150089 | V3–V4 | Illumina-MiSeq |
| IBS-D (30) | 32.1 ± 8.11 | ± 3.26 | ||||||
| Presti_2019 (Lo Presti et al., 2019) | HC (47), IBS (44) | 54, 48 | 23, 24 | 20/27, 30/14 | ||||
| IBS-D (16) | ||||||||
| IBS-C (18) | NA | NA | NA | Italy | SRP110018 | V1-V3 | 454 GS Junior | |
| IBS- A (10) | ||||||||
| Pozuelo_2015 (Pozuelo et al., 2015) | HC (66), IBS (113) | 37.6 ± 13, 42.6 ± 13 | 23.7 ± 3.4, 23.7 ± 4 | 40/26, 80/33 | ||||
| IBS-D (54) | 41.9 ± 13 | 25 ± 4.6 | 29/25 | |||||
| IBS-C (32) | 39.4 ± 10.8 | 23.3 ± 3.8 | 31/2 | Spain | SRP050404 | V4 | Illumina-MiSeq | |
| IBS-M (27) | 48.2 ± 16.4 | 23.9 ± 3.6 | 32/8 | |||||
| Zhu_2019 (Zhu et al., 2019) | HC (15) | 28.27 ± 1.56 | NA | 7/8 | China | SRP222428 | V4 | Illumina-HiSeq |
| IBS(15) | 47.67 ± 14.24 | 1/2 | ||||||
| Saulnier_2011 (Saulnier et al., 2011) | HC (22), IBS (22) | 9.32 ± 1.52, 9.41 ± 1.04 | NA | 11/11, 8/14 | US | SRP002457 | 454 GS FLX | |
| IBS-D (1) | 9.38 ± 1.19 | 5/8 | ||||||
| IBS-C (13) | 10 | 0/1 | V1-V3 | |||||
| IBS-U (7) | 9.26 ± 1.89 | 3/4 | V3-v5 | |||||
| other (1) | 9 | 0/1 | ||||||
| Labus_2017 (Labus et al., 2017) | HC (23), IBS (29) | 26.0 ± 6.48, 26.1 ± 5.72 | 14/9, 21/8 | |||||
| IBS-D (10) | ||||||||
| IBS-C (11) | ||||||||
| IBS-M (5) | NA | NA | NA | US | SRP099239 | V3-V5 | 454 GS FLX | |
| IBS-A (1) | ||||||||
| IBS-U (2) |
NA, data not available; IBS, irritable bowel syndrome; HC, healthy controls; IBS-D, diarrhea-predominant IBS; IBS-C, constipation-predominant IBS; IBS-M, mixed IBS; IBS-A, alternating IBS; IBS-U, unsubtyped IBS.