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. 2021 Jun 22;9(6):e002553. doi: 10.1136/jitc-2021-002553

Figure 2.

Figure 2

Kaplan-Meier for cardiac biomarkers at onset and 90-day mortality. Each breakpoint was determined based on the maximized Youden’s Index obtained by receiver operating characteristic curves. (A) Kaplan-Meier of the relationship between troponin ≥3.73 ng/mL and 90-day myocarditis-associated mortality. Troponin elevation ≥3.73 ng/mL was associated with a statistically significantly increased risk of mortality (HR 10.34, 95% CI 1.07 to 100, p=0.044). (B) Kaplan-Meier of the relationship between creatine kinase (CK) at onset of ≥1153 IU/L and 90-day myocarditis-associated mortality. CK elevation of ≥1153 IU/L was associated with an increased risk of mortality (HR 4.26, 95% CI 0.60 to 30, p=0.115) but this relationship was not statistically significant. (C) Kaplan-Meier of the relationship between CK-MB at onset of ≥99 ng/mL and 90-day myocarditis-associated mortality. CK-MB elevation of ≥99 ng/mL was associated with an increased risk of mortality (HR 5.18, 95% CI 0.70 to 38, p=0.106), but this relationship was not statistically significant.