Table 3.
Outcome | Assessment |
Fertilisation | Fertilisation rate per aspirated oocyte retrieved (16–20 hours after IVF/ICSI) defined as the appearance of 2 pronuclei |
Cycles with total fertilisation failure | |
Embryo data | Embryo quality (ie, good quality blastocysts according to Gardner classification) |
Embryo time-lapse kinetics including cleavage patterns | |
Embryo utilisation rate (number of transferred + cryopreserved embryos per number of 2 PN zygotes) | |
Freeze | Number of frozen blastocysts (time frame: up to 6 days after oocyte pick up (OPU)) |
Pregnancy | Positive pregnancy test (positive urine or serum hCG 11-21 days after embryo transfer) |
Multiple pregnancy (period: up to 12 weeks after embryo transfer). Number of intrauterine gestations | |
Ongoing pregnancy per transfer (fetal heartbeat on ultrasound in gestational week 7–8) | |
Miscarriage | Pregnancy loss rate (period: up to 12 weeks after embryo transfer) |
Biochemical pregnancies (positive urine or serum hCG 11-21 days after embryo transfer without any clinical signs of intra- or extrauterine pregnancy) | |
Ectopic pregnancy/PUL | |
Birth/offspring | All live birth episodes (all live births from the study oocyte collection (including second and further live births) |
Preterm delivery (delivery at gestational week 22–36+6) | |
Birth weight/weight for gestational age | |
Congenital anomaly diagnosed at birth |
ICSI, intracytoplasmic sperm injection; IVF, in vitro fertilisation; OPU, oocyte pick up; PN, pronuclei; PUL, pregnancy of unknown location.