Table 3.

Changes in functional neuroimaging parameters over time in the Cerebrolysin and placebo groups.

	Cerebrolysin Group			Placebo Group			p-Value
	T0	T2	p-Value	T0	T2	p-Value
Diffusion tensor imaging
Corticospinal tract	0.901 ± 0.070	0.816 ± 0.095	<0.001 *	0.885 ± 0.084	0.757 ± 0.113	<0.001 *	0.0167 †
Superior corona radiata	0.887 ± 0.103	0.833 ± 0.145	<0.001 *	0.859 ± 0.115	0.747 ± 0.175	<0.001 *	0.0185 †
Superior longitudinal fasciculus	0.917 ± 0.145	0.861 ± 0.199	<0.001 *	0.908 ± 0.127	0.800 ± 0.225	<0.001 *	0.0305 †
Whole hemispheric tracts	0.935 ± 0.063	0.897 ± 0.082	<0.001 *	0.925 ± 0.064	0.856 ± 0.110	<0.001 *	0.0263 †
Genu of corpus callosum	0.480 ± 0.046	0.465 ± 0.050	<0.001 *	0.485 ± 0.039	0.455 ± 0.056	<0.001 *	0.0091 †
Body of corpus callosum	0.516 ± 0.054	0.494 ± 0.056	<0.001 *	0.523 ± 0.042	0.486 ± 0.062	<0.001 *	0.0256 †
Splenium of corpus callosum	0.629 ± 0.059	0.612 ± 0.061	<0.001 *	0.638 ± 0.044	0.611 ± 0.058	<0.001 *	0.0449 †
Resting-state functional imaging
Ipsilesional connectivity	0.222 ± 0.088	0.217 ± 0.079	0.6735	0.238 ± 0.065	0.191 ± 0.078	0.0014 *	0.0280 †
Contralesional connectivity	0.295 ± 0.084	0.270 ± 0.074	0.0741	0.292 ± 0.059	0.281 ± 0.086	0.4588	0.4866
Interhemispheric connectivity	0.436 ± 0.151	0.448 ± 0.137	0.5095	0.403 ± 0.151	0.415 ± 0.151	0.5825	0.9731
Network efficiency	0.313 ± 0.057	0.302 ± 0.060	0.2386	0.314 ± 0.044	0.294 ± 0.058	0.0270 *	0.4600

* p < 0.05, Comparison with value at T0; ^† p < 0.05, Interaction between time and type of intervention; T0, Baseline assessment at 8 days after stroke onset; T1, After 21 days of Cerebrolysin or placebo intervention; T2, 90 days after stroke onset; Diffusion tensor imaging (Cerebrolysin n = 50, Placebo n = 42), Resting-state functional magnetic resonance imaging (Cerebrolysin n = 43, Placebo n = 38.