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. 2021 Jun 11;57(6):607. doi: 10.3390/medicina57060607

Table 1.

Cytokines and proliferation marker Ki67 positive structures in samples of nasal polyps and significant differences between them and the control group.

Factors/Subjects IL-1α IL-4 IL-6 IL-7 IL-8 IL-10 IL-12 Ki 67
E CT E CT E CT E CT E CT E CT E CT E CT
1 ++ +++ ++ ++/+++ ++ +++ ++ +++ ++ +++ ++ +++ ++/+++ +++ + +
2 +++ +++ ++ ++/+++ ++ ++/+++ + ++ ++ ++ +++ +++ ++ +++ +/++ +
3 ++ ++ + ++ + +++ ++ +++ +/++ ++ ++ +++ + +++ ++ +
4 0/+ ++ + ++ ++ +++ ++ ++ ++ ++ ++/+++ +++ ++/+++ +++ 0/+ 0/+
5 0/+ +/++ + 0/+ 0 + ++ 0/+
6 + +/++ + + + +/++ + ++/+++ 0/+ + + + ++ +++ 0 +
7 +/++ ++/+++ +/++ +++ + +++ +/++ +++ 0 + 0 0/+ ++ ++/+++ ++ +
8 ++ ++ + ++ +/++ ++/+++ +/++ ++ + + +/++ +/++ +++ ++ 0 0
9 + + ++ + + + + 0
10 + + + ++/+++ + ++/+++ + ++/+++ 0 + + +/++ ++ +++ ++ +
11 0/+ + + ++/+++ ++ +++ +/++ +++ + +/++ +/++ ++/+++ ++ +++ +/++ ++/+++
12 0/+ +/++ ++ ++/+++ +/++ ++/+++ +/++ ++ + + ++ ++ +++ ++++ ++ ++
Average +/++ ++ +/++ ++ +/++ ++/+++ +/++ ++ + +/++ +/++ ++ ++ +++ + +
Control ++/+++ 0/+ +++ +/++ +++ + +++ +/++ +++/++++ + ++++ ++ +++ + +/++ 0/+
Significant Difference (p-value) 0.001 <0.001 <0.001 0.014 <0.001 <0.001 <0.001 0.006 <0.001 0.028 <0.001 0.811 0.002 <0.001 0.309 0.073

Abbreviations: E—epithelium; CT—connective tissue; Ki 67—proliferation marker; IL-1α —interleukin 1 alpha; IL-4—interleukin 4; IL-6—interleukin 6; IL-7—interleukin 7; IL-8—interleukin 8; IL-10—interleukin 10; IL-12—interleukin 12; 0/+—occasional positive structures, +—few positive structures, +/++—few to moderate number of positive structures, ++—moderate number of positive structures, ++/+++—moderate to numerous positive structures, +++—numerous positive cells, +++/++++—numerous to abundance of structures, ++++—abundance of positive structures in the visual field.