Figure 5.

Correlation of TCR-β similarities before and during the anti-PD-1 treatment with response and prognostic variables in NSCLC patients. (a) Jaccard index in patients with durable clinical benefit (DCB; in green) and non-durable clinical benefit (non-DCB; in orange). p-value was obtained using the Fisher’s exact test. Each column represents a patient. (b) Kaplan–Meier progression-free survival (PFS) curves according to the Jaccard similarity index. Jaccard similarity index was calculated as the total number of shared clones divided by the total number of unique clones across PRE and FR samples of the same patient and the median = 0.0605 was used as the cutoff value to define high (blue line) and low (red line) groups. p-value was obtained using the log-rank test.