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. 2021 Jun 12;10(6):709. doi: 10.3390/antibiotics10060709

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Percentage of activity of E. coli DHFR after a 30-min incubation. Each histogram represents the activity of DHFR in the presence of different concentrations of H₂F and 5 µM of the inhibitors (a) TMP, (b) 1a and (c) 1b. The data are expressed as a percentage with respect to the control.