Table 1.

Minimum inhibitory concentration (MIC, µM) of trimethoprim (TMP) and compounds 1a and 1b tested alone and in combination with sulfamethoxazole (SMX) and colistin against Escherichia coli ATCC 25922, Pseudomonas aeruginosa PAO1, and Serratia marcescens NIMA. Data for P. aeruginosa PAO1 and E. coli ATCC 25922 were already reported [6].

	MIC (µM)
Antimicrobial	E. coli ATCC 25922	P. aeruginosa PA01	S. marcescens NIMA
TMP	0.43	>110.22	13.78
TMP (SMX)	0.11 (2.37)	13.78 (315.86)	0.86 (19.74)
1a	1.25	>80.10	80.10
1a (SMX)	0.63 (19.74)	40.05 (1263.43)	2.5 (78.96)
1b	1.02	>65.50	16.37
1b (SMX)	0.13 (3.95)	32.75 (1263.43)	1.02 (39.48)
Colistin	0.43	1.73	>886.23