Table 2.
The minimum biofilm eradication concentration (MBEC, μM) and biofilm prevention concentration (BPC, μM) of TMP and the GBBR analogues 1a and 1b when tested alone and in combination with SMX (1:20) against E. coli ATCC 25922, S. aureus ATCC 29213, and S. aureus 8124825998.
| Antimicrobial | E. coli ATCC 25922 | S. aureus ATCC 29213 | S. aureus 8124825998 | |||
|---|---|---|---|---|---|---|
| MBEC (μM) | BPC (μM) | MBEC (μM) | BPC (μM) | MBEC (μM) | BPC (μM) | |
| TMP (SMX) |
275.56 (6317.14) |
275.56 (6317.14) |
>2204.46 (50,537.15) | 1102.23 (25,268.58) | >2204.46 (50,537.15) | >2204.46 (50,537.15) |
|
1a (SMX) |
>1602.06 (50,537.15) |
200.26 (6317.14) |
>1602.06 (50,537.15) | 801.03 (25,268.58) |
>1602.06 (50,537.15) | >1602.06 (50,537.15) |
|
1b (SMX) |
163.74 (6317.14) |
81.87 (3158.57) |
>1309.91 (50,537.15) | 163.74 (6317.14) |
>1309.91 (50,537.15) | 327.48 (12,634.29) |