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. 2021 Jun 11;22(12):6298. doi: 10.3390/ijms22126298

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The somatosensory cortex of 6-months-old 5xFAD mice displays abundant amyloid beta (Aβ) load. Low (a + c) and high-magnification (b + d) confocal images of biocytin-filled pyramidal cells in the somatosensory cortex of a 6-months-old 5xFAD mouse and wildtype (WT) mouse. Biocytin-filled neurons were detected by fluorescently labelled streptavidin (Streptavidin-A594; left panel). Aβ protein was detected with the 6E10 antibody coupled to A488 (6E10-A488; middle panel). Merges of both channels are shown in the right panel.