Table 5a.
Comparison of baseline measurements of each biomarkers that changed with post-vaccination of AERAS-402.
| Genes | day 0 and day 7Ψ | day 0 and day 28Ψ | day 0 and day 35Ψ | day 0 and day 42¥ | day 0 and day 182¥ | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean difference | SE Mean | p-value | Mean difference | SE Mean | p-value | Mean difference | SE Mean | p-value | Mean difference | SE Mean | p-value | Mean difference | SE Mean | p-value | ||
| Type-1 IFN inducible | CXCL10 | 451.7 | 367.9 | 0.265 | 859.4 | 537.4 | 0.161 | 142.7 | 293.0 | 0.643 | 268.4 | 841.1 | 0.470 | 587.5 | 78.6 | 0.001 |
| IFI35 | 468.4 | 873.0 | 0.611 | 1671.3 | 1283.8 | 0.241 | -617.0 | 1076.7 | 0.578 | 305.1 | 1077.2 | 0.789 | 2702.7 | 895.7 | 0.030 | |
| IFIT3 | 683.6 | 469.5 | 0.196 | 576.0 | 357.1 | 0.158 | 919.4 | 1218.4 | 0.479 | 118.0 | 476.1 | 0.815 | 1424.2 | 431.0 | 0.021 | |
| TAP2 | 232.1 | 304.9 | 0.475 | 513.7 | 200.4 | 0.043 | 250.0 | 248.1 | 0.353 | -127.0 | 246.4 | 0.626 | 22.7 | 345.4 | 0.950 | |
| Hanekom set | BMP6 | 1838.4 | 1822.5 | 0.352 | 995.7 | 1243.5 | 0.454 | 345.4 | 1058.1 | 0.755 | 1412.2 | 1173.3 | 0.909 | 3552.0 | 1134.9 | 0.026 |
| GUSB | 293.7 | 257.6 | 0.298 | 376.1 | 218.8 | 0.136 | 131.6 | 163.3 | 0.451 | 137.1 | 148.2 | 0.399 | 818.8 | 287.3 | 0.036 | |
| KIF1B | 491.9 | 260.8 | 0.108 | 324.7 | 225.0 | 0.199 | 268.4 | 140.6 | 0.105 | 122.3 | 191.1 | 0.552 | 457.7 | 154.3 | 0.031 | |
| LYN | 383.9 | 162.2 | 0.056 | 1336.7 | 383.2 | 0.013 | 655.3 | 291.2 | 0.065 | 711.2 | 336.4 | 0.088 | 1796.5 | 1036.8 | 0.144 | |
| VEGF | -18.4 | 21.0 | 0.413 | 133.1 | 86.8 | 0.176 | 130.4 | 51.6 | 0.045 | 276.3 | 64.3 | 0.008 | -29.8 | 39.5 | 0.484 | |
| Innate and adaptive | CCL5 | 6127.4 | 2222.7 | 0.033 | 2371.1 | 1947.8 | 0.269 | 3833.6 | 1562.6 | 0.050 | -544.1 | 1364.4 | 0.710 | 3306.2 | 2832.9 | 0.296 |
| CCR7 | 715.3 | 349.6 | 0.087 | 450.3 | 216.6 | 0.083 | 1173.3 | 336.8 | 0.013 | 446.4 | 393.2 | 0.320 | 319.8 | 326.5 | 0.372 | |
| CD3E | 3363.9 | 1015.1 | 0.016 | 2700.3 | 885.1 | 0.022 | 2821.0 | 954.2 | 0.025 | 671.0 | 1066.1 | 0.564 | 1407.0 | 867.2 | 0.166 | |
| CD8A | 979.9 | 557.8 | 0.129 | 580.9 | 480.6 | 0.272 | 1470.4 | 515.5 | 0.029 | 37.6 | 586.2 | 0.952 | 497.2 | 781.8 | 0.553 | |
| CLEC7A | 1627.7 | 696.3 | 0.056 | 1932.7 | 800.4 | 0.050 | 1372.4 | 407.9 | 0.015 | 1213.6 | 409.3 | 0.041 | 1907.2 | 595.9 | 0.024 | |
| CXCL13 | 581.1 | 185.3 | 0.020 | 313.6 | 163.8 | 0.104 | 312.0 | 88.6 | 0.012 | 290.0 | 229.4 | 0.275 | 373.8 | 169.6 | 0.079 | |
| GATA3 | 179.9 | 65.5 | 0.033 | 122.1 | 41.4 | 0.026 | 83.3 | 55.6 | 0.185 | 68.8 | 78.2 | 0.429 | 45.7 | 63.0 | 0.501 | |
| GZMA | -734.4 | 720.0 | 0.347 | -2111.6 | 542.5 | 0.008 | -1690.9 | 688.0 | 0.049 | -2813.0 | 502.2 | 0.005 | 821.8 | 1800.9 | 0.667 | |
| NLRC4 | -128.1 | 154.4 | 0.438 | -81.1 | 50.8 | 0.161 | -358.4 | 110.7 | 0.018 | 389.0 | 452.4 | 0.438 | 417.0 | 321.4 | 0.251 | |
| NLRP1 | 2473.6 | 1179.9 | 0.081 | 2599.7 | 692.8 | 0.009 | 2436.4 | 406.2 | 0.001 | 1425.4 | 940.8 | 0.240 | 1971.8 | 1466.9 | 0.237 | |
| NLRP3 | 166.0 | 148.5 | 0.306 | 674.3 | 197.6 | 0.014 | 389.9 | 172.6 | 0.001 | 752.9 | 89.8 | 0.001 | 63.7 | 177.6 | 0.735 | |
| NOD1 | 321.9 | 169.7 | 0.107 | 390.9 | 153.2 | 0.043 | 256.0 | 66.3 | 0.008 | 46.6 | 264.7 | 0.869 | 258.3 | 143.2 | 0.131 | |
| PTPRCv1 | 3436.4 | 862.3 | 0.007 | 2378.7 | 833.5 | 0.029 | 2426.3 | 622.1 | 0.008 | 1613.6 | 914.0 | 0.152 | 2243.3 | 847.3 | 0.046 | |
| PTPRCv2 | 927.0 | 359.7 | 0.042 | 709.6 | 371.1 | 0.104 | 791.6 | 170.3 | 0.004 | -145.0 | 370.2 | 0.716 | 769.8 | 504.9 | 0.188 | |
| TAGAP | 2718.0 | 809.5 | 0.015 | 1475.1 | 467.7 | 0.020 | 2064.0 | 568.9 | 0.011 | 356.8 | 604.1 | 0.587 | 1906.0 | 713.8 | 0.044 | |
| TLR4 | -26.9 | 53.8 | 0.636 | 77.6 | 38.2 | 0.088 | -77.3 | 68.3 | 0.301 | 131.2 | 148.0 | 0.428 | 340.0 | 124.1 | 0.041 | |
| TLR7 | -763.0 | 304.2 | 0.046 | -223.0 | 327.8 | 0.522 | -603.1 | 315.6 | 0.105 | -257.4 | 682.3 | 0.725 | 290.7 | 193.3 | 0.193 | |
| ZNF331 | 437.0 | 244.6 | 0.124 | 210.4 | 100.0 | 0.080 | 920.1 | 300.4 | 0.022 | 741.0 | 192.4 | 0.018 | 17.3 | 30.6 | 0.596 | |
Ψ - 7 subjects; ¥ - 6 subjects. SE, Standard error; p-value obtained based on paired t-test. The significant p-values are in bold.