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. 2021 Jun 24;36(1):1378–1386. doi: 10.1080/14756366.2021.1928111

Scheme 1.

Scheme 1.

Reagents and conditions: (i) succinic anhydride, triethylamine, dry methylene chloride, reflux, 6 h; (ii) 1-hydroxymethyl-5-fluorouracil, EDC·HCl, DMAP, dry methylene chloride/acetonitrile (1:1, v/v), rt, 12 h.