Table 1.
Active TB Disease Status at Study Enrollment Among Adult Patients With Pulmonary TB Who Initiated Second-Line Anti-TB Treatment Within the Georgian National TB Program During 2011–2014 and Were Subsequently Defined as LFU (N = 92 Study Participants Who Were Tested)
| Characteristics | Total | TB+ | TB− | ||
|---|---|---|---|---|---|
| Na (%) = 92 (100) | n (%) = 13 (14) | n (%) = 79 (86) | OR (95% CI) | P Value | |
| Demographics | |||||
| Gender | .69 | ||||
| Male | 82 (89.1) | 12 (14.6) | 70 (85.4) | 1.5 (0.2–13.3) | |
| Female | 10 (10.9) | 1 (10.0) | 9 (90.0) | 1b | |
| Age* | |||||
| Median (IQR) | 42.5 (15.9) | 40.5 (13) | 43 (16.4) | .62c | |
| Age Categories | .82 | ||||
| 0–40 | 38 (41.3) | 5 (13.2) | 33 (86.8) | 1 | |
| 41+ | 54 (58.7) | 8 (14.8) | 46 (85.2) | 1.2 (0.3–3.8) | |
| Region | .38 | ||||
| Tbilisi | 26 (28.3) | 5 (19.2) | 21 (80.8) | 1.7 (0.5–5.9) | |
| Other | 66 (71.7) | 8 (12.1) | 58 (87.9) | 1 | |
| Employment Status | .48 | ||||
| Employed | 21 (23.1) | 2 (9.5) | 19 (90.5) | 1 | |
| Unemployed | 70 (76.9) | 11 (15.7) | 59 (84.3) | 1.8 (0.4–8.7) | |
| Income* | |||||
| Median (IQR) | 3600 (3600) | 3600 (1800) | 3840 (3600) | .73c | |
| Education | .38 | ||||
| High School or low | 68 (74.7) | 11 (16.2) | 57 (83.8) | 2.0 (0.4–9.9) | |
| Above High School | 23 (25.3) | 2 (8.7) | 21 (91.3) | 1 | |
| Marital Status | .28 | ||||
| Currently married | 55 (61.1) | 6 (10.9) | 49 (89.1) | 1 | |
| Never married | 21 (23.3) | 6 (28.6) | 15 (71.4) | 3.3 (0.9–11.6) | |
| Widow | 0 (0) | 0 (0) | 0 (0) | - | |
| Divorced | 12 (13.3) | 1 (8.3) | 11 (91.7) | 0.7 (0.1–6.8) | |
| Missing/Refusal | 2 (2.2) | 2 (100) | 0 (0) | - | |
| Number of household members (in addition to patient) | |||||
| Median (IQR) | 3 (2) | 3 (4) | 3 (2) | .75c | |
| Drug intake regularity during the latest episode of treatment | .22 | ||||
| Regular | 75 (81.5) | 9 (12) | 66 (88) | 1 | |
| Irregular | 17 (18.5) | 4 (23.5) | 13 (76.5) | 2.3 (0.6–8.4) | |
| Medicine Intake During the Latest Episode of Treatment | .63 | ||||
| All prescribed drugs | 62 (67.4) | 8 (12.9) | 54 (87.1) | 1 | |
| Not all prescribed drugs | 30 (32.6) | 5 (16.7) | 25 (83.3) | 1.4 (0.4–4.6) | |
| Treatment Adherence (Combined Variable) | .33 | ||||
| Full adherence | 55 (59.8) | 7 (12.7) | 48 (87.3) | 1 | |
| Partial adherence | 27 (29.3) | 3 (11.1) | 24 (88.9) | 0.9 (0.2–3.6) | |
| No adherence | 10 (10.9) | 3 (30.0) | 7 (70.0) | 2.9 (0.6–14.1) | |
| Culture Status Before LFU | <.01 | ||||
| Negative | 74 (84.1) | 3 (4.1) | 71 (95.9) | 1 | |
| Positive | 14 (15.9) | 8 (57.1) | 6 (42.9) | 31.6 (6.6–151.2) | |
| Re-Enter Treatment After Initial LFU | .03 | ||||
| Yes | 38 (41.3) | 9 (23.7) | 29 (76.3) | 3.9 (1.1–13.7) | |
| No | 54 (58.7) | 4 (7.4) | 50 (92.6) | 1 | |
| Days on Treatment During Last Episode* | |||||
| Median (IQR) | 341 (290) | 171 (391) | 342 (258) | .15c | |
| Days From LFU to Study Enrollment* | |||||
| Median (IQR) | 1095 (715) | 480 (803) | 1119 (627) | <.01c | |
| Current Signs and Symptoms | |||||
| Cough | .73 | ||||
| Yes | 18 (19.6) | 3 (16.7) | 15 (83.3) | 1.3 (0.3–5.2) | |
| No | 74 (80.4) | 10 (13.5) | 64 (86.5) | 1 | |
| Cough With Blood or Vomiting Blood During the Last 3 Months | |||||
| Yes | 2 (2.2) | 0 (0) | 2 (100) | ||
| No | 90 (97.8) | 13 (14.4) | 77 (85.6) | ||
| Fever | .99 | ||||
| Yes | 7 (7.6) | 1 (14.3) | 6 (85.7) | 1.0 | |
| No | 85 (92.4) | 12 (14.1) | 73 (85.9) | 1 | |
| Significant Weight Loss (≥3 kg in 1 Month) | .68 | ||||
| Yes | 10 (11) | 1 (10) | 9 (90) | 0.6 (0.1–5.5) | |
| No | 81 (89) | 12 (14.8) | 69 (85.2) | 1 | |
| Night Sweats | .91 | ||||
| Yes | 15 (16.5) | 2 (13.3) | 13 (86.7) | 0.9 (0.2–4.6) | |
| No | 76 (83.5) | 11 (14.5) | 65 (85.5) | 1 | |
| Chest Pain | .83 | ||||
| Yes | 19 (20.9) | 3 (15.8) | 16 (84.2) | 1.2 (0.3–4.7) | |
| No | 72 (79.1) | 10 (13.9) | 62 (86.1) | 1 |
Abbreviations: CI, confidence interval; IQR, interquartile range; LFU, loss to follow-up; OR, odds ratio; TB, tuberculosis.
NOTE: Continuous variables (*) are presented as median (IQR), and categorical variables are summarized as frequencies (valid percentage).
aIndividual variable totals might not sum up to 92 due to missing values.
b1 = reference value.
c P value from Wilcoxon signed-rank test.