Table 2.

Multivariable Analysis for Association Between History to TB Retreatment, Treatment Duration, and Mtb Culture Status Before LFU With Risk of Active TB Disease Among Adult Patients With Pulmonary TB Who Initiated Second-Line Anti-TB Treatment Within the Georgian National TB Program During 2011–2014 and Were Subsequently Defined as LFU (N = 92 Study Participants Who Were Tested)

Characteristics	RR (95% CI)	aRR (95% CI)a	aRR (95% CI)b
Exposure 1: History of re-entering TB treatment	3.2 (1.1–9.6)	3.7 (1.1–12.7)	1.5 (0.4–5.3)c
Exposure 2: Treatment duration (per 30 day increase)	0.9 (0.8–1.0)	0.9 (0.8–1.0)	0.9 (0.8–1.0)d
Exposure 3: Positive Mtb culture before LFU	14.1 (4.3–46.7)	18.7 (4.5–77.8)	13.3 (4.2–42.2)e

Abbreviations: aRR, adjusted risk ratio; CI, confidence interval; LFU, loss to follow-up; RR, risk ratio; TB, tuberculosis.

^aAdjusted for age and sex. All aRRs were estimated using robust Poisson regression models.

^bSee Supplemental Figure 1 for corresponding directed acyclic graphs. In assessment of goodness of fit, none of the adjusted models suggested evidence of poor fit (all devicance P > .05).

^cAdjusted for age, Mtb culture before LFU, and combined treatment adherence variable. Sex was not included in the model due to collinearity with Mtb culture before LFU and re-entering TB treatment.

^dAdjusted for age, sex, and combined treatment adherence variable.

^eAdjusted for age and combined treatment adherence variable. Sex was not included in the model due to collinearity with Mtb culture before LFU.