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. 2021 Jun 22;43(1):968–979. doi: 10.1080/0886022X.2021.1936040

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Effects of ATF4 knockdown on HO-1 expression on podocytes exposed to serum from DN mice. (A) Protein expression analysis revealed that HO-1 expression was increased by serum from DN mice, indicating increased ER stress, while ATF4 siRNA significantly reduced HO-1 expression in MCP-5 podocyte. (B) Densitometric analysis of protein expression from Figure 4(A) (**p < 0.01, *p < 0.05).