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. 2021 Jun 11;8:656151. doi: 10.3389/fmolb.2021.656151

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Copyright © 2021 Liu, Yu, Ge, Zhao, Miao, Jin, Su, Geng, Chen, Xie, Cui, Yao, Li, Hou and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BAP31 promoted HCC cell migration and invasion via Snail and there was positive correlation between BAP31 and Snail in HCC. (A–B) Transwell assay analysis of the migratory and invasive abilities of Huh7 and Li-7 cells, which were divided into four groups: vector, BAP31-NC, BAP31-shSnail-1 and BAP31-shSnail-2. Representative images (upper) and the statistical analysis (lower) were shown. Results were presented as mean ± SD and t-test was conducted between BAP31-NC and BAP31-shSnail-1/-2 group (n = 3, *p < 0.05, **p < 0.01). (C–D) Western blot analysis showed the positive correlation between protein expression of BAP31 and Snail in HCC tissues (n = 28, p = 0.022, r = 0.430).