TABLE 1.
Lanthipeptide producers and applications
| Lanthipeptide(s) | Producer strain | Class, subclass | Type testeda | Bioactivity (reference[s]) |
|---|---|---|---|---|
| Nisin | Lactococcus lactis | I, nisin-like | In vivo, in vitro, TC | Antimicrobial (160), anticancer (129), immunomodulatory (46) |
| Subtilin | Bacillus subtilis | I, nisin-like | In vitro, in vivo | Antimicrobial (161, 162) |
| Ericin | Bacillus subtilis | I, nisin-like | In vitro | Antimicrobial (163) |
| CMB001 | Paenibacillus kyungheensis | I, nisin-like | In vitro | Antimicrobial (33) |
| Gallidermin/epidermin | Staphylococcus gallinarum/S. epidermidis | I, epidermin-like | In vitro, TC | Antimicrobial (164), immunomodulatory (47) |
| Clausin | Bacillus clausii | I, epidermin-like | In vitro, in vivo | Antimicrobial (27) |
| Mutacin 1140 | Streptococcus mutans | I, epidermin-like | In vitro, in vivo, TC | Antimicrobial (40, 165) |
| Mutacin B-Ny266 | Streptococcus mutans | I, epidermin-like | In vitro, in vivo | Antimicrobial (98, 166) |
| Planosporicin | Planispora alba | I, planosporicin-like | In vivo, in vitro | Antimicrobial (28, 82) |
| NAI-107 (microbisporicin) | Microspora corallina | I, planosporicin-like | In vivo, in vitro | Antimicrobial (28, 29) |
| Mersacidin | Bacillus amyloliquefaciens | II, mersacidin-like | In vitro, in vivo | Antimicrobial (31, 34) |
| Actagardine | Actinoplanes liguraie | II, mersacidin-like | In vivo, in vitro | Antimicrobial (79, 167) |
| Duramycin/cinnamycin | Streptomyces cinnamoneus | II, cinnamycin-like | In vitro, in vivo, TC | Antimicrobial (168), antiviral (141, 168), anticancer (135, 136), ion channel regulator (50, 51), immunomodulatory (121) |
| Lacticin-3147 | Lactococcus lactis | II, mersacidin-like; II, Ltn2-like | In vivo, in vitro | Antimicrobial (32, 169) |
| Amyloliquecidin | Bacillus amyloliquefaciens | II, mersacidin-like; II, Ltn2-like | In vivo, in vitro | Antimicrobial (27) |
| Pinensins | Chitinophaga pinensins | I, pinensin-like | In vitro | Antimicrobial (170), antifungal (170) |
| Labyrinthopeptins | Actinomadura namibiensis | III, labyrinthopeptin-like | In vivo, in vitro, TC | Antiviral (44), antiallodynic (16) |
| NAI-112 | Actinoplanes sp. strain DSM 24059 | III, labyrinthopeptin-like | In vivo, in vitro | Antimicrobial (mild) (48), antiallodynic (48), antinociceptive (48) |
a
TC, tissue culture.