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. 2021 Jun 24;16(1):919–930. doi: 10.1515/med-2021-0253

Figure 4.

Figure 4

lncRNA TUG1 negatively regulated the expression of miR-493-3p and miR-410-3p by sponging miR-493-3p and miR-410-3p. (a) Online database starBase was adopted to make inferences about the underlying binding sequences between TUG1 and miR-493-3p or miR-410-3p in N2a cells. (b and c) Dual-luciferase reporter system presented the combination between TUG1 and miR-493-3p or miR-410-3p in N2a cells. (d and e) The expression of miR-493-3p and miR-410-3p was measured by RT-qPCR in N2a cells with or without being treated by OGD/R. (f and g) The expression of miR-493-3p and miR-410-3p was measured by RT-qPCR in the serum of CIRI patients and normal people. (h and i) Spearman’s correlation analysis was employed to analyze the relationship between the expression of TUG1 and miR-493-3p or miR-410-3p. *P < 0.05.