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. 2021 Jun 24;16(1):919–930. doi: 10.1515/med-2021-0253

Figure 6.

Figure 6

The inhibition of miR-493-3p or miR-410-3p could restore the reverse effects of TUG1 knockdown on OGD/R-mediated decrease in inflammation and oxidative stress in N2a cells in vitro. (a–c) The concentration of TNF-α , IL-6 and IL-1β was measured by ELISA in N2a cells, which transfected with si-TUG1#2 + anti-miR-493-3p or si-TUG1#2 + anti-miR-410-3p or negative controls, with or without being treated by OGD/R. (d) The effect of si-TUG1#2 and anti-miR-493-3p or anti-miR-410-3p on ROS generation was analyzed by Reactive oxygen species assay kit in N2a cells with or without being treated by OGD/R. (e–g) The intracellular levels of MDA, SOD and LDH were measured by colorimetry in N2a cells, which transfected with si-TUG1#2 + anti-miR-493-3p or si-TUG1#2 + anti-miR-410-3p or negative controls, with or without being treated by OGD/R. *P < 0.05.