Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 12;13(6):1133. doi: 10.3390/v13061133

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Neutralization activity of convalescent sera against replication-competent SARS-CoV-2. (A) Serum activity against the purified SARS-CoV-2 virions. Serial fourfold dilutions of serum samples from convalescent donors were incubated with SARS-CoV-2 and added to the Vero E6 cells. Cell survival was determined 5 days later by MTT test and expressed as a percentage of cytopathic effect (CPE) inhibition measured relative to untreated control, which was set at 100%. (B) Correlation between NT₅₀ serum-neutralizing titers measured with the ΔFΔC19-PVs and the live SARS-CoV-2. (C) Serum-neutralizing activity against SARS-CoV-2 in cell coculture conditions. Serial fourfold dilutions of serum samples from convalescent donors were incubated with SARS-CoV-2 infected Vero E6 cells, which were then mixed with uninfected Vero E6 cells at a 1:2 ratio. The results were collected and presented as in (A). The average results from three independent experiments with standard deviations are shown in (A,C).