Table 2.
Laboratory variables.
| Reference Range | Non-Persistent Airflow Limitation n = 45 |
Persistent Airflow Limitation n = 47 |
Control n = 36 |
p-Value Non-Persistent vs. Persistent Limitation |
p-Value Non-Persistent Limitation vs. Control |
p-Value Persistent Limitation vs. Control |
|
|---|---|---|---|---|---|---|---|
| Basic laboratory tests | |||||||
| Red blood cells, 106/μL | 4–5 | 4.65 ± 0.4 | 4.7 ± 0.5 | 4.48 ± 0.4 | 0.68 | 0.048 | 0.03 |
| White blood cells, 103/μL | 4–10 | 6.26 (5.43–7.33) | 7.44 (6.39–9.25) | 5.44 (5.16–7.08) | <0.001 | 0.07 | <0.001 |
| Neutrophils, 103/μL | 1.8–7.7 | 3.1 (2.7–4.1) | 3.7 (2.9–4.8) | 3.3 (2.9–3.6) | 0.049 | 0.76 | 0.04 |
| Lymphocytes, 103/μL | 1–4.5 | 1.94 (1.58–2.43) | 2.2 (1.58–2.61) | 1.65 (1.44–2.08) | 0.5 | 0.03 | 0.03 |
| Monocytes, 103/μL | 0.1–0.8 | 0.57 (0.49–0.74) | 0.71 (0.53–0.9) | 0.49 (0.41–0.62) | 0.02 | 0.006 | <0.001 |
| Blood platelets, 103/μL | 140–400 | 223 (193–247) | 225 (191–265) | 228 (189–246) | 0.78 | 0.98 | 0.85 |
| Asthma and inflammatory biomarkers (blood) | |||||||
| Eosinophilia/μL | 40–450 | 230 (130–310) | 400 (180–680) | 110 (70–170) | 0.009 | <0.001 | <0.001 |
| Immunoglobulin E, IU/mL | 0–100 | 90 (26–400) | 88 (43–511) | 23 (18–48) | 0.6 | <0.001 | <0.001 |
| C-reactive protein, mg/L | 0–5 | 1.64 (0.53–8) | 4.53 (0.58–9.38) | 1.78 (0.89–2.29) | 0.39 | 0.28 | 0.008 |
| Fibrinogen, g/L | 1.8–3.5 | 3.1 (2.8–3.5) | 3.5 (3.2–4.2) | 2.9 (2.3–3.7) | 0.03 | 0.11 | 0.002 |
| Periostin, ng/mL | 0.29–0.61 § | 0.28 (0.24–0.33) | 0.38 (0.31–0.51) | 0.37 (0.36–0.45) | 0.01 | 0.001 | 0.85 |
| Interleukin 6, pg/mL | 0.005–1.432 § | 0.72 (0.43–1.19) | 1.09 (0.47–2.38) | 0.57 (0.43–0.97) | 0.14 | 0.29 | 0.03 |
| Interleukin 10, pg/mL | 0.163–1.022 § | 0.6 (0.22–1.06) | 0.55 (0.35–0.89) | 0.43 (0.2–0.76) | 0.95 | 0.17 | 0.1 |
| Interleukin 12 (p70), pg/mL | 0.005–2.618 § | 0.005 (0.005–1.2) | 0.005 (0.005–1.25) | 0.005 (0.005–0.33) | 0.7 | 0.13 | 0.26 |
| ADAM-33, ng/mL | 0.083–2.257 § | 0.73 (0.2–1.29) | 1.32 (0.33–2.37) | 0.41 (0.13–1.5) | 0.01 | 0.65 | 0.007 |
| Circulating integrin subunits | |||||||
| α1 integrin, ng/mL | 6.45–103.67 § | 17.32 (6.88–52.4) | 32.7 (14.7–55.7) | 24.1 (8.90–76.5) | 0.14 | 0.21 | 0.83 |
| α2 integrin, ng/mL | 7.79–36.19 § | 15.5 (9.7–25.5) | 22.9 (15–39) | 20.5 (11.7–26.5) | 0.03 | 0.25 | 0.21 |
| Asthma and inflammatory biomarkers (bronchoalveolar lavage fluid) | |||||||
| Periostin, ng/mL | 0.1–1.15 § | 0.86 (0.8–0.99) | 0.81 (0.72–0.95) | 0.8 (0.51–0.88) | 0.34 | 0.17 | 0.49 |
| Eosinophils, % | 0–1 # | 0.5 (0–1) | 1 (0.1–3) | 0.1 (0–1) | 0.02 | 0.62 | 0.006 |
Table 2 footnote. Variables are presented as median and interquartile range or mean and standard deviation, as appropriate; §—reference range based on the 10th and 90th percentile values in the control group, #—reference according to the American Thoracic Society Guidelines [26]; Abbreviation: ADAM-33—a disintegrin and metalloproteinase domain-containing protein 33. Statistics: Mann–Whitney U-test or unpaired t-test, as appropriate.