Table 1.
IC50 (inhibitory concentration) values of the cisplatin and resveratrol were determined using a linear regression equation for the cytotoxicity curve for PE/CA-PJ49, FaDu tumor cells and for HaCaT normal cells. IC50 values are presented as mean ± SEM according to two independent assays, each done in triplicate. The Selectivity Index (SI) = IC50 of a compound in a normal cell line/IC50 of the same compound in a cancer cell line. SI values of more than 2 were considered as high selectivity.
| IC50 | SI | ||||
|---|---|---|---|---|---|
| 24 h Treatment |
HaCaT | PE/CA-PJ49 | FaDu | HaCaT/PE/CA-PJ49 | HaCaT/FaDu |
| CisPt (µM) | 23.9+/−1.6 | 9.1+/−2.1 | 12.1+/−1.9 | 2.63 | 1.97 |
| RSV (µM) | 94.7+/−2.9 | 44.9+/−3.1 | 39.3+/−1.9 | 2.15 | 2.41 |