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. 2021 Jun 15;1(8):1147–1157. doi: 10.1021/jacsau.1c00139

Figure 5.

Figure 5

Scheme depicting features of SARS-CoV-2 N protein during infection. N protein undergoes proteolysis to produce N1–209, N1–220, N1–273, N156–419, and N1–392. NFL and N proteoforms bind RNA with a preference for structured RNA, and NFL dimers are likely functional unit of assembly in ribonucleoprotein complexes. Immunophilin CypA binds directly to N1–209 but not NFL, and the interaction can be inhibited through addition of cyclosporin A (CsA). N156–419 and NFL interact with antibodies from convalescent plasma, while proteoforms N1–209, N1–220, and N1–273 fail to induce the same antibody response.