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. Author manuscript; available in PMC: 2023 Sep 5.
Published in final edited form as: J Am Soc Mass Spectrom. 2021 Jun 14;32(7):1618–1630. doi: 10.1021/jasms.1c00086

Figure 4.

Figure 4.

Overlay of HDX-MS and XL-MS results on nsp7 and nsp8 sequences. Observed inter-nsp7 nsp8 crosslinks only identified in the nsp7:nsp8 1:1 complex are colored in orange and inter-nsp7 nsp8 crosslinks also identified in nsp7:nsp8 1:2 complex are colored in blue. Consolidated change in percent deuterium uptake from Fig 1C and 1D are overlayed on the nsp7 and nsp8 sequences, respectively. Initial Met residue removed from both nsp7 and nsp8 sequences to maintain correct residue numbering.