Table 4.
Distances of inter-nsp7 nsp8-I crosslinks mapped to available SARS-CoV-2 apo polymerase complex structures composed of nsp7, nsp8, and nsp12.
nsp7 position | nsp8 position | PDB: 7BV1 | PDB: 7BW4 | PDB: 7BTF | PDB: 6M71 | |
---|---|---|---|---|---|---|
Distance (Å) | Distance (Å) | Distance (Å) | Distance (Å) | Distance (Å) | ||
27 | 79 | 29.3 | NF | NF | NF | NF |
27 | 196 | NF | NF | NF | NF | NF |
27 | 127 | 16.9 | 17.1 | 16.3 | 17.2 | NF |
70 | 79 | 18.5 | NF | NF | NF | NF |
7 | 79 | 26.8 | NF | NF | NF | NF |
43 | 79 | 37.3 | NF | NF | NF | NF |
57 | 97 | 17.9 | 17.7 | 18.0 | 17.9 | 18.2 |
7 | 97 | 13.0 | 13.3 | 13.5 | 13.2 | 13.0 |
2 | 97 | 9.4 | 10.2 | 10.8 | 10.1 | 10.5 |