. Author manuscript; available in PMC: 2023 Sep 5.

Published in final edited form as: J Am Soc Mass Spectrom. 2021 Jun 14;32(7):1618–1630. doi: 10.1021/jasms.1c00086

Table 5.

Distances of inter-nsp7 nsp8-I crosslinks mapped to available SARS-CoV-2 replicating polymerase complex structures composed of nsp7, nsp8, nsp12, and RNA.

nsp7 position	nsp8 position	PDB: 6YHU	Pre-translocation State	Post-translocation State
		PDB: 6YHU	PDB: 6YYT	PDB: 7BZF	PDB: 6XQB
		Distance (Å)	Distance (Å)	Distance (Å)	Distance (Å)
27	79	29.3	30.9	NF	NF
27	196	NF	NF	NF	NF
27	127	16.9	17.6	17.2	NF
70	79	18.5	22.1	NF	NF
7	79	26.8	23.4	NF	NF
43	79	37.3	33.9	NF	NF
57	97	17.9	17.7	18.3	19.3
7	97	13.0	13.3	13.2	13.1
2	97	9.4	10.3	10.4	9.5