(A) and (B) are adjusted for age, sex, race-center, smoking status, estimated glomerular filtration rate, hypertension, diabetes, heart failure, atherosclerotic cardiovascular disease (coronary heart disease or stroke), total cholesterol, high-density lipoprotein-cholesterol and lipid lowering medication. Statistically significant decreases in weight were observed when NT-proBNP levels increased by more than 59.1 pg/mL (A) and 54.8 pg/mL (B) in the 6-year follow up. Decreases in NT-proBNP levels of more than 22.3 pg/mL over the same period were associated with statistically significant increases in weight (A).