Table 1.
Characteristics of participants according to NT-proBNP quartiles at baseline (visit 2, 1990-1992), the Atherosclerosis Risk in Communities (ARIC), n=9681
| Q1 (≤ 27.17 pg/mL) |
Q2 (27.19 – 50.79 pg/mL) |
Q3 (50.81 – 90.58 pg/mL) |
Q4 (≥ 90.63 pg/mL) |
P-value for trend |
|
|---|---|---|---|---|---|
| N | 2,422 | 2,419 | 2,421 | 2,419 | |
| Age, years | 55.0 (5.3) | 56.3 (5.4) | 57.2 (5.7) | 58.3 (5.7) | <0.0001 |
| Female (%) | 838 (34.6%) | 1270 (52.5%) | 1611 (66.5%) | 1727 (71.4%) | <0.0001 |
| Race (%) | |||||
| White | 1644 (67.9%) | 1908 (78.9%) | 2004 (82.8%) | 2029 (83.9%) | <0.0001 |
| Black | 778 (32.1%) | 511 (21.1%) | 417 (17.2%) | 390 (16.1%) | <0.0001 |
| Current smokers (%) | 474 (19.6%) | 431 (17.8%) | 466 (19.2%) | 492 (20.3%) | 0.164 |
| Hypertension (%) | 727 (30.0%) | 709 (29.3%) | 755 (31.2%) | 1003 (41.5%) | <0.0001 |
| Diabetes (%) | 393 (16.2%) | 320 (13.2%) | 274 (11.3%) | 258 (10.7%) | <0.0001 |
| History of coronary heart disease or stroke (%) | 62 (2.6%) | 87 (3.6%) | 124 (5.1%) | 289 (11.9%) | |
| Prevalent heart failure (%) | 74 (3.1%) | 88 (3.6%) | 72 (3.0%) | 140 (5.8%) | <0.0001 |
| Use of medication for hypertension, diabetes or lipid lowering (%) | 779 (32.2%) | 762 (31.5%) | 784 (32.4%) | 1061 (43.9%) | <0.0001 |
| Weight, kg | 84.1 ± 15.3 | 80.6 ± 16.0 | 76.7 ± 16.8 | 75.6 ± 17.1 | <0.0001 |
| BMI, kg/m2 | 28.7 ± 4.9 | 28.2 ± 5.0 | 27.5 ± 5.5 | 27.3 ± 5.5 | <0.0001 |
| Obesity [BMI≥30 kg/m2] (%) | 781 (32.2%) | 716 (29.6%) | 622 (25.7%) | 622 (25.7%) | <0.0001 |
| Waist circumference, cm | 100.3 ± 12.4 | 98.8 ± 13.3 | 96.1 ± 14.6 | 95.4 ± 15.2 | <0.0001 |
| Glucose, mg/dL | 102.1 (94.4, 112.6) | 99.2 (92.5, 107.8) | 97.3 (90.6, 104.9) | 96.3 (90.6, 104.9) | <0.0001 |
| Glycated hemoglobin, %-point | 5.5 (5.2, 5.9) | 5.4 (5.2, 5.8) | 5.4 (5.2, 5.7) | 5.4 (5.2, 5.7) | <0.0001 |
| Triglycerides, mg/dL | 126.1 (90.5, 178.8) | 117.9 (85.5, 166.7) | 112.9 (82.4, 160.6) | 111.8 (82.4, 156.5) | <0.0001 |
| HDL-cholesterol, mg/dL | 20.1 (17.9, 23.0) | 20.9 (17.9, 23.8) | 21.6 (18.7, 26.0) | 22.3 (18.7, 26.7) | <0.0001 |
| Total cholesterol, mg/dL | 204.7 (180.8, 231.5) | 203.7 (179.8, 228.5) | 202.7 (180.8, 227.5) | 201.7 (178.8, 227.5) | 0.005 |
| CRP, mg/L | 2.0 (1.0, 4.0) | 2.1 (1.0, 4.4) | 2.3 (1.1, 4.9) | 2.6 (1.2, 5.7) | <0.0001 |
| eGFR, mL/min/1.73 m2 | 99.1 (91.3, 107.6) | 97.7 (89.5, 105.3) | 96.9 (89.0, 104.8) | 95.6 (86.1, 103.3) | <0.0001 |
Data is presented as number (%), mean ± standard deviation or median (interquartile range). BMI=Body mass index; CRP=C-Reactive Protein; eGFR=Estimated glomerular filtration rate; HDL=High-density lipoprotein