Table 2.
Baseline characteristics, treatment, and outcomes for fresh, nondonor cycles among Hispanic, Asian, and WNH women with prior ART.
| Prior ART | Prior ART | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hispanic (n = 4544) | White (n = 44,126) | Asian (n = 11,987) | White (n = 44,126) | ||||||||
| Characteristics (% Reporting) | % | 95% CI | % | 95% CI | p | Characteristics (% Reporting) | % | 95% CI | % | 95% CI | p |
| Women’s age (year) | <0.001 | Women’s age (year) | <0.001 | ||||||||
| <35 | 23.6 | (22.4–24.9) | 32.7 | (32.2–33.1) | <35 | 21.7 | (20.9–22.4) | 32.7 | (32.2–33.1) | ||
| 35–37 | 22 | (20.8–23.2) | 21.9 | (21.5–22.3) | 35–37 | 18.6 | (17.9–19.3) | 21.9 | (21.5–22.3) | ||
| 38–40 | 26.4 | (25.1–27.7) | 22.1 | (21.7–22.4) | 38–40 | 24.6 | (23.8–25.4) | 22.1 | (21.7–22.4) | ||
| 41–42 | 15.1 | (14.1–16.2) | 11.8 | (11.5–12.1) | 41–42 | 16.5 | (15.8–17.2) | 11.8 | (11.5–12.1) | ||
| >42 | 13 | (12.0–14.0) | 11.7 | (11.4–12) | >42 | 18.7 | (18.0–19.4) | 11.7 | (11.4–12) | ||
| Nulliparous (49.6) | 45.7 | (43.8–47.5) | 44.4 | (43.8–44.9) | 0.188 | Nulliparous (48.6) | 50.9 | (49.7–52.1) | 44.4 | (43.8–44.9) | <0.001 |
| Past spontaneous abortions | 34.4 | (33.1–35.8) | 32.8 | (32.4–33.3) | 0.028 | Past spontaneous abortions | 32.3 | (31.5–33.2) | 32.8 | (32.4–33.3) | 0.311 |
| Diagnosis | Diagnosis | ||||||||||
| Tubal Factor | 22.6 | (21.4–23.8) | 10.4 | (10.2–10.7) | <0.001 | Tubal Factor | 10.7 | (10.1–11.2) | 10.4 | (10.2–10.7) | 0.496 |
| Tubal Ligation | 5.3 | (4.7–6.0) | 1 | (0.9–1.1) | <0.001 | Tubal Ligation | 0.5 | (0.3–0.6) | 1 | (0.9–1.1) | <0.001 |
| Hydrosalpinx | 2 | (1.6–2.5) | 0.7 | (0.6–0.8) | <0.001 | Hydrosalpinx | 1.3 | (1.1–1.6) | 0.7 | (0.6–0.8) | <0.001 |
| Other | 15.6 | (14.5–16.7) | 8.8 | (8.6–9.2) | <0.001 | Other | 9.2 | (8.7–9.7) | 8.8 | (8.6–9.2) | 0.27 |
| Male Infertility | 32.5 | (31.2–33.9) | 36 | (35.5–36.4) | <0.001 | Male Infertility | 28.4 | (27.6–29.2) | 36 | (35.5–36.4) | <0.001 |
| Uterine Factor | 6.8 | (6.1–7.6) | 4.5 | (4.3–4.7) | <0.001 | Uterine Factor | 5.5 | (5.1–6.0) | 4.5 | (4.3–4.7) | <0.001 |
| History of endometriosis | 8.8 | (8.0–9.7) | 9.8 | (9.5–10.1) | 0.033 | History of endometriosis | 7.5 | (7.0–8.0) | 9.8 | (9.5–10.1) | <0.001 |
| Diminished ovarian reserve | 44.2 | (42.8–45.7) | 41.3 | (40.8–41.7) | <0.001 | Diminished ovarian reserve | 52.4 | (51.5–53.3) | 41.3 | (40.8–41.7) | <0.001 |
| Unexplained | 7.2 | (6.5–8.0) | 10.4 | (10.1–10.7) | <0.001 | Unexplained | 9.8 | (9.3–10.3) | 10.4 | (10.1–10.7) | 0.059 |
| Ovulation Disorder (PCOS) | 9.6 | (8.8–10.5) | 10.2 | (10.0–10.5) | 0.183 | Ovulation Disorder (PCOS) | 7.4 | (7.0–7.9) | 10.2 | (10.0–10.5) | <0.001 |
| Other | 18.3 | (17.2–19.5) | 21.2 | (20.9–21.6) | <0.001 | Other | 23.5 | (22.7–24.3) | 21.2 | (20.9–21.6) | <0.001 |
| Day 3 FSH <10 IU/L | 3.2 | (2.7–3.8) | 4 | (3.8–4.2) | 0.014 | Day 3 FSH <10 IU/L | 4 | (3.7–4.4) | 4 | (3.8–4.2) | 0.855 |
| Day 3 FSH >10 IU/L | 77.6 | (76.4–79.0) | 74 | (73.6–74.4) | <0.001 | Day 3 FSH >10 IU/L | 76.5 | (75.8–77.3) | 74 | (73.6–74.4) | <0.001 |
| FSH dosage ≥ 37 ampules (93.7) | 64.5 | (63.0–66.0) | 64.8 | (64.3–65.2) | 0.716 | FSH dosage ≥ 37 ampules (93.5) | 60.6 | (59.6–61.5) | 64.8 | (64.3–65.2) | <0.001 |
| AMH <1 among women < 40 yr | 21.6 | (20.1–23.2) | 21 | (20.6–21.5) | 0.471 | AMH <1 among women < 40 yr | 18.6 | (17.7–19.6) | 21 | (20.6–21.5) | <0.001 |
| High ovarian response | 1.1 | (0.9–1.5) | 0.7 | (0.7–0.8) | 0.005 | High ovarian response | 1.2 | (1.1–1.5) | 0.7 | (0.7–0.8) | <0.001 |
| Cycle Cancelled | 15.3 | (14.3–16.4) | 13.3 | (13.0–13.6) | <0.001 | Cycle Cancelled | 13 | (12.4–13.6) | 13.3 | (13.0–13.6) | 0.302 |
| Due to low response | 74.4 | (70.9–77.6) | 80.1 | (79.1–81.1) | 0.001 | Due to low response | 76.1 | (73.9–78.2) | 80.1 | (79.1–81.1) | 0.001 |
| ICSI | 60.9 | (59.5–62.3) | 63.9 | (63.4–64.3) | <0.001 | ICSI | 58.5 | (57.6–59.4) | 63.9 | (63.4–64.3) | <0.001 |
| No of embryos | <0.001 | No of embryos | <0.001 | ||||||||
| 1 | 21.8 | (20.2–23.4) | 26.3 | (25.8–26.8) | 1 | 28.2 | (27.0–29.4) | 26.3 | (25.8–26.8) | ||
| 2 | 55.7 | (53.8–57.6) | 53.1 | (52.5–53.7) | 2 | 48.3 | (47.0–49.7) | 53.1 | (52.5–53.7) | ||
| 3+ | 22.5 | (21.0–24.2) | 20.6 | (20.1–21.1) | 3+ | 23.5 | (22.3–24.6) | 20.6 | (20.1–21.1) | ||
| No. of embryos transferred: mean (sd) | 2.08 (0.86) | 2.02 (0.88) | <0.001 | No. of embryos transferred: mean (sd) | 2.08 (1.03) | 2.02 (0.88) | <0.001 | ||||
| Implantation rate %: mean (sd) | 60.83 (33.08) | 67.08 (34.1) | <0.001 | Implantation rate %: mean (sd) | 63.71 (36.73) | 67.08 (34.1) | <0.001 | ||||
| Treatment outcome | Treatment outcome | ||||||||||
| Clinical intrauterine gestation (CIG) | 22.5 | (21.3–23.8) | 25.1 | (24.7–25.5) | <0.001 | Clinical intrauterine gestation (CIG) | 15.6 | (15.0–16.3) | 25.1 | (24.7–25.5) | <0.001 |
| Spontaneous abortion | 23.2 | (20.6–25.9) | 18.6 | (17.8–19.3) | <0.001 | Spontaneous abortion | 23.8 | (21.9–25.8) | 18.6 | (17.8–19.3) | <0.001 |
| Live birth per CIG | 74.9 | (72.1–77.5) | 80.5 | (79.7–81.2) | <0.001 | Live birth per CIG | 75 | (73.0–77.0) | 80.5 | (79.7–81.2) | <0.001 |
| Biochemical pregnancy | 4.9 | (4.3–5.6) | 5.7 | (5.5–6.0) | 0.025 | Biochemical pregnancy | 4.3 | (3.9–4.6) | 5.7 | (5.5–6.0) | <0.001 |
| Ectopic or heterotopic | 0.6 | (0.4–0.9) | 0.5 | (0.4–0.6) | 0.533 | Ectopic or heterotopic | 0.4 | (0.3–0.5) | 0.5 | (0.4–0.6) | 0.109 |
| Not preganant | 62.8 | (61.4–64.2) | 58.3 | (57.8–58.7) | <0.001 | Not preganant | 63.2 | (62.3–64.0) | 58.3 | (57.8–58.7) | <0.001 |
| Live birth per cycle started | 16.9 | (15.8–18.0) | 20.2 | (19.8–20.6) | <0.001 | Live birth per cycle started | 11.7 | (11.2–12.3) | 20.2 | (19.8–20.6) | <0.001 |
| Plurality of birth (24.6) | 0.217 | Plurality of birth (23.1) | 0.019 | ||||||||
| Singleton | 76.5 | (73.4–79.5) | 75.8 | (74.9–76.6) | Singleton | 79.2 | (77.0–81.3) | 75.8 | (74.9–76.6) | ||
| Twins | 21.1 | (18.4–24.2) | 22.6 | (21.8–23.5) | Twins | 19.4 | (17.4–21.6) | 22.6 | (21.8–23.5) | ||
| Triples or more | 2.3 | (1.4–3.7) | 1.6 | (1.3–1.9) | Triples or more | 1.4 | (0.8–2.2) | 1.6 | (1.3–1.9) | ||
| eSET (%) < 38 y/o (44.7) | 10.4 | (9.2–11.9) | 13.9 | (13.4–14.3) | <0.001 | eSET (%) < 38 y/o (42.8) | 13.2 | (12.2–14.2) | 13.9 | (13.4–14.3) | 0.22 |
| BMI ≥ 30 | 39.9 | (38.5–41.3) | 34.5 | (34.1–35.0) | <0.001 | BMI ≥ 30 | 6.4 | (6.0–6.9) | 34.5 | (34.1–35.0) | <0.001 |
| States | 0.001 | States | <0.001 | ||||||||
| Mandated | 30.1 | (28.8–31.5) | 32.4 | (32.0–32.9) | Mandated | 27.3 | (26.5–28.1) | 32.4 | (32.0–32.9) | ||
| Non-mandated | 69.8 | (68.4–71.1) | 67 | (66.5–67.4) | Non-mandated | 72.6 | (71.8–73.4) | 67 | (66.5–67.4) | ||