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. 2021 Jun 13;10(6):1491. doi: 10.3390/cells10061491

Figure 1.

Figure 1

PI3K/PTEN signaling controls the activation of primordial follicles in the ovary. In dormant oocytes (left), PTEN reverts PIP2 back to PIP3 and prevents follicular activation. The downstream transcription factor Foxo3 is expressed in the nucleus. In growing oocytes (right), the PI3K–Akt signaling pathway is activated by converting PIP2 to PIP3. PIP3 then recruits both PDK1 and Akt to the cell membrane where PDK1 phosphorylates and activates Akt, resulting in Foxo3 hyperphosphorylation and nuclear export, which triggers the activation of the primordial follicle.