Figure 5.

Illustration of kinetic models with increasing complexity, starting with the precursor-product model (left), separation of intravascular and extravascular physical compartments (middle), and further separation of an intracellular compartment (right). Precursor-product models (left) are the easiest to apply, but two physical compartment models (middle) have been shown to be more appropriate for in vivo HP data and will more accurately estimate metabolic conversion rates without vascular contamination. Figure adapted from Ref. [88].