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Relationship between maximal ThT fluorescence and protein concentration of post-mortem sCJD CSF samples. The set of post-mortem sCJD samples (n = 18) was analyzed by second-generation RT-QuIC undiluted (red circles) and 10× diluted (blue squares). The protein concentrations of the samples were determined by the BCA method. The CSF samples with a protein concentration above 2.5 g/L inhibited the RT-QuIC reaction. Dilution of the samples eliminated the inhibiting effect on the assay.
