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. 2021 Jun 13;10(6):1489. doi: 10.3390/cells10061489

Figure 7.

Figure 7

Post-treatment with the HSP90 inhibitor, AUY-922, repairs HCl-induced HLMVEC barrier dysfunction. HLMVEC were seeded on 8W10E+ arrays; when confluent (R > 800 Ω), 0.01 N HCl (final concentration) was added (black arrow). At the nadir of the observed TER values, 2 µM (final concentration) AUY-922 (grey arrow) or vehicle was added. TER was recorded continuously with an interval time of 10 s and normalized to time = 0 h. Post-treatment with AUY-922 completely restored endothelial barrier function. Means ± SEM; n = 3. ***: p < 0.001 between HCl and HCl + AUY groups, one-way ANOVA with Bonferroni’s post-test.