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Quantification of cfDNA mutations in time-matched CSF and plasma of patients with brain metastasis. The amount of mutated DNA within the total cell-free DNA is shown as the mutant allele fraction (% AF). Blue and red squares denote the presence or absence, respectively, of detectable mutations in cfDNA in CSF or PL. AF, allele fraction; cfDNA, cell-free DNA; IP, intraparenchymal; LMD, leptomeningeal disease; ND, not detected; PL, plasma.
