Figure 3.

Transcriptional changes after TBI in tau-KO male and female flies. Volcano plots depicting log2 fold change and –log10 (PV: p-value) of differentially expressed genes at 1, 2 and 4 h after injury compared to control are indicated for males (A–C) and females (D–F) (n = 3 for each condition: male and female at control, 1, 2 and 4 h post-TBI).The number of significantly upregulated and downregulated gene changes are indicated in yellow in each plot (|log2FC| > 1; p-value < 0.05). Tau-KO males show more transcriptional upregulation of genes in response to injury than females.