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. 2021 Jun 15;10(6):955. doi: 10.3390/antiox10060955

Figure 1.

Figure 1

A single blast overpressure (BOP) caused increased tau phosphorylation in the mouse brain. (A) Representative Western blots demonstrated the early elevation of phospho-tau (Ser202/Thr205 detected by AT8, pS262, and Ser396/Ser404 detected by PHF1 antibody and pathological conformation changes of tau (Alz50) in the cortex after blast (n = 5/group). Tau-5 was probed to detect total tau. (B–E) Quantification analysis of AT8 (B), Alz50 (C), pS262 (D), and PHF1 (E) normalized to total tau detected b they tau 5 antibody. (Data are means ± SEM, * p < 0.05, ** p < 0.01; ns, non-significant). TBI: traumatic brain injury.