Table 1.
Host gene and genomic location of miRNA clusters.
| Cluster Chromosome |
Host Gene/Locus Name | Host Gene Type | Cluster Location | Expression Regulation and Transcription Site (TSS) |
|---|---|---|---|---|
| miR-106a/18b/20b/19b-2/92a-2 chr. X |
Xq26.2 [15] |
Non-coding | intergenic | Own TSS [10] |
| miR-106b/93/25 chr. 7 |
MCM7 [15] |
Protein coding | intron | Co-expression of miR-25 with the host gene [16]. Host gene TSS [17,18,19] |
| miR-17/18a/19a/20a/19b-1/92a-1 chr.13 |
MIR17HG [15] |
Long non-coding | intron | Co-expression of miR-17, miR-18a, miR-20a and miR-92a with the host gene [16,20]. Multiple TSS [10,11] |
| miR-181a-1/181b-1 chr. 1 |
MIR181A1HG [21] |
Long non-coding |
intron | Multiple TSS [10] |
| miR-181a-2/181b-2 chr. 9 |
NR6A1 [22] |
Protein coding | intron | Multiple TSS [10] |
| miR-181c/181d chr. 19 |
NANOS3 [22,23,24] |
Protein coding | intron | Own TSS [10] |
| miR-183/96/182 chr. 7 |
MIR96 [23,24] |
Non-coding | intergenic | Own TSS [10] |
| miR-191/425 chr. 3 |
NDUFA3 [16] |
Protein coding | intron | Host gene TSS [25] |
| miR-200c/141 chr. 12 |
MIR200CHG [26] |
Long non-coding |
intergenic | Own TSS [27] |
| miR-203a/203b chr. 14 |
MIR203A [28] |
Non-coding | intergenic | Own TSS [10] |
| miR-222/221 chr. X |
MIR222HG [25] |
Long non-coding | intergenic | Own TSS [10] |
| miR-23a/27a/24-2 chr. 19 |
MIR23AHG [26] |
Long non-coding | intergenic | Own TSS [29] |
| miR-29b-1/29a chr. 7 |
LINC-PINT [30] |
Long non-coding | intergenic | Multiple TSS [10] |
| miR-301b/miR-130b chr. 22 |
PPIL2 [31] |
Protein coding | intron | Multiple TSS [10] |
| miR-452/224 chr. X |
GABRE [9] |
Protein coding | intron | Co-expression with the host gene [17,18,19] |
Abbreviations—MCM7 (minichromosome maintenance complex component 7), MIR17HG (miR-17-92a-1 cluster host gene), MIR181A1HG (MIR181A1 host gene), NR6A1 (nuclear receptor subfamily 6 group A member 1), NANOS3 (nanos C2HC-type zinc finger 3), NDUFA3 (NADH:ubiquinone oxidoreductase subunit A3), MIR200CHG (MIR200C and MIR141 host gene), MIR222HG (miR222/221 cluster host gene), MIR23AHG (miR-23a/27a/24-2 cluster host gene), LINC-PINT (long intergenic non-protein coding RNA, p53 induced transcript), PPIL2 (peptidylprolyl isomerase like 2), GABRE (gamma-aminobutyric acid type A receptor subunit epsilon). TSS—transcription start site.