Table 6.
List of target genes of up-regulated miRNA clusters.
| Cluster | miRNA | Target Genes |
|---|---|---|
| miR-106a/18b/20b/19b-2/ 92a-2/363 |
miR-106a-5p | ATG7; AMER1; DUSP2; FOXQ1; GABBR1; TGFBR2 |
| miR-106a-3p | PTEN | |
| miR-18b-5p | CDKN2B; SOX9 | |
| miR-20b-5p | ADAM9; GABBR1; POU5F1 | |
| miR-19b-3p | SMAD4 | |
| miR-92a-5p | AQP8 | |
| miR-92a-3p | BCL2L11; DDK3; FBXW7; GSK3β; KLF4; MOAP1; NF2; RBM4; RECK; SMAD7 | |
| miR-363-3p | EZH2; GATA6; SOX4; SPHK2 | |
| miR-106b/25/93 | miR-106b-5p | ATG16L1; CTSA; DLC1; GABBR1; ITGB8; CDKN1A; PLK3; PRRX1; PTEN; SLAIN2; TRIM8 |
| miR-10b-3p | DLC1 | |
| miR-25-5p | NEDD9; PRKCZ | |
| miR-25-3p | ANGPTL8; ATXN3; MCU; SEMA4C; SMAD7 | |
| miR-93-5p | ATG12; ATG16L1; CCND1; CD274; CTNNB1; FOXA1; HIF1A; MYC; PTEN; SMAD7 | |
| miR-93-3p | ARID4B | |
| miR-17/18a/19a/20a/19b-1/92a-1 | miR-17-5p | BTG3; CLU; CYP7B1; GABBR1; NCOA3; PTEN; RBL2; RND3; SIK1 TGFBR2; TRIM8; VIM |
| miR-17-3p | F2RL3 | |
| miR-18a-5p | ATM; CCND1; CDC42; CDK19; HIF1A; HNRNPA1; ING4; NEDD9; PIAS3; SMAD4; TBPL1 | |
| miR-19a-3p | FOXF2; KRAS; PTEN; TF; TGFBR2; TGM2; THBS1; TIA1; TNFAIP3 | |
| miR-20a-5p | AMER1; ATG5; BID; BNIP2; CDKN1A; CXCL8; FOXJ2; GABBR1; MAP3K5; MICA; PDCD4; RB1CC1; SMAD4; TGFBR2; VEGFA | |
| miR-19b-3p | SMAD4 | |
| miR-92a-5p | AQP8 | |
| miR-92a-3p | BCL2L11; DDK3; FBXW7; GSK3β; KLF4; MOAP1; NF2; RBM4; RECK; SMAD7; PTEN | |
| miR-181a-1/181b-1miR-181a-2/181b-2 | miR-181a-5p | CTNNB1; E2F5; MMP14; PLAG1; PTEN; SRCIN1; STAT1; TCF4; WIF1 |
| miR-181b-5p | PDCD4; PIAS3; RASSF1; TUSC3 | |
| miR-181c/181d | miR-181d-5p | PEAK1; FBXL3; CRY2 |
| miR-183/96/182 | miR-183-5p | ABCA1; AFDN; AKAP12; ATG5; RCN2; UVRAG |
| miR-96-5p | CCND1; FOXO1; FOXO3a; GPC1; KRAS; TP53INP1; TPM1 | |
| miR-96-3p | RECK | |
| miR-182-5p | AGER; DAB2IP; FBXW7; FOXF2; FOXO1; FOXO3a; MTDH; MYC; SATB2; ST6GALNAC2; THBS1 | |
| miR-191/425 | miR-191-5p | C/EBPβ; TIMP3 |
| miR-425-5p | CTNND1; PDCD10 | |
| miR-200c/141 | miR-200c-3p | BMI1; CDK2; ETS1; FLT1; KLF14; SOX2; VLDLR; ZEB1 |
| miR-200c-5p | PRICKLE2 | |
| miR-141-3p | CCND2; DLC1; EGFR; GEMIN2; MAP2K4; MAP4K4; PDCD4; SIRT1; TRAF5; ZEB1 | |
| miR-203a/203b | miR-203a-3p | AKT2; ATM; CPEB4; CREB1; CSE1L; CTNNB1; DNMT3b; EIF5A2; GATA6; NEDD9; PDE4D; RNF6; ROBO1; SIK2; TCF4; THBS2; TLE5; TYMS; KLK6 |
| miR-203b-3p | BCL2L1 | |
| miR-221/222 | miR-221-5p | MBD2 |
| miR-23a/27a/24-2 | miR-23a-3p | ABCF1; APAF1; MARK1; PDK4; SEMA6D |
| miR-27a-3p | BTG1; CALR; FAM172A; RXRα; SFRP1; SGPP1; SMAD2; TP53; VANGL | |
| miR-24-5p | CTNNB1 | |
| miR-24-3p | DHFR; DND1; VHL | |
| miR-29b-1/29a | miR-29b-3p | BCL9L; GRN; SIRT1; TIAM1 |
| miR-29b-5p | SMAD3 | |
| miR-29a-3p | KLF4; MMP2; PTEN; RPS15A; TNFAIP3 | |
| miR-301b/130b | miR-130b-3p | ITGB1; ITGA5 |
| miR-452/224 | miR-224-5p | CDH1; CDKN1A; CDS2; GSK3β; LGALSL; MBD2; PHLPP1; PHLPP2; SFRP2; SLC4A4; SMAD4; USP3 |
| miR-452-3p | GSK3β |
Genes with tumour suppresor function are bolded in this table.